Abstract
Urinary organic acid of neonate and adult were analyzed by the use of gas chromatography (GLC) and gas chromatography-mass spectrometry (GC-MS) after extraction with diethyl ether at pH 1. Similar chromatograms were obtained from urines of both neonate and adult. Standard deviations of all peaks were relatively low in neonates as compared with those of the adults. None of specific compound was found in neonatal urine, that is, almost the same kinds of compounds were found to be excreted in nearly the same quantity in urine of neonate and adult. Although fatty acids of palmitic acid and stearic acid are excreted in fairly large amounts into neonatal urine, this may be due to milk fat intake. And excretion of large amounts of fumaric acid and succinic acid in neonate suggests more synthesis of ATP due to neonatal development. A relatively less amounts of 4-hydroxyphenylacetic acid and homovanillic acid was excreted in urine of the neonate, because of altered tyrosine metabolism due to enhancement of protein synthesis.
