Abstract
It has been known that pathological findings of herpes shimplex encephalitis first described by Smith et al. (1941) were almost similar to those of acute necrotiging encephalitis (van Bogaert et al., 1955). In those cases, necrotic lesions were seen in the cerebral basal surface (mainly the temporal lobe), and intranuclear inclusions of Cowdry A type were found in the oligodendrocytes and nerve cells. We would like to report two cases showing similarr histopathological findings to those of van Bogaert and electronmicroscopically containing herpes simplex like particles in their oligodendrocytes. However, laboratory examinations such as viral isolation, demonstration of virus by use of fluorescence antibody techniques and serum antibody titer were not carried out in the present cases.
