STUDIES ON THE ANTIBODY RESPONSE TO LIVE POLIOVIRUS VACCINE (SABIN STRAIN)

Abstract

Vaccination with monovalent or trivalent Sabin's oral poliovirus vaccine has been progressing in Fukuoka Prefecture, Kyushu, Japan, since July 1961. By October 1961, approximately 762, 422 children representing 43.3% of the population under the age of ten years had been vaccinated.In relation to the prevention of poliomyelitis it is important to find out whatrange and degree the antibody formation would be stimulated by oral vaccination not only in general but especially in view of the interference of live vaccine to the other enteric viruses which are considered to be highly incident in Japan.The present studies were performed by the use of the serological method in order to clarify the antibody response of the vaccinated and unvaccinated children to the live poliovirus vaccine and, in addition, to infer the nature of the infection by the other enteric viruses, ECHO and Coxsackie virus strains.