The Kurume Medical Journal
Online ISSN : 1881-2090
Print ISSN : 0023-5679
ISSN-L : 0023-5679
Volume 8, Issue 2-3
Displaying 1-7 of 7 articles from this issue
  • MASAHISA SHINGU, YOH NAKAGAWA
    1961 Volume 8 Issue 2-3 Pages 61-69
    Published: June 30, 1962
    Released on J-STAGE: February 08, 2010
    JOURNAL FREE ACCESS
    Within the past several years, studies have been made of at least seven markers of poliovirus which can be determined by tissue culture, physical property and serological method, and which tend to discriminate between neurovirulent and attenuated strains.Strains possessing the d+ marker grow more rapidly than d-strains at low bicarbonate concentration under agar ; strains possessing the MS+marker grow more rapidly on the monkey kidney stable cell line than MS-strains ; strains possessing the T+marker grow readily at 40°C in contrast to the T-strains ; Cf antigen of strains possessing the CFt+marker are more resistant than CFt-strains at various temperatures ; strains possessing the A+marker grow more rapidly on the primary human amnion cell than A-strain ; strains possessing the E+marker elute more rapidly from an DEAE column than E-strain.The most promising advance in the identification of virus strains is the intratypic serodifferentiation test investigated by McBride, Gard and Wecker.However, in these studies they observed principally the change in the primary monkey kidney cells, without touching on the established cell lines.This paper will be concerned chiefly with the d, T, MS, and CFt marker test on the established cell lines.
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  • SHINICHIRO OTA, RYOKO YAMAUCHI
    1961 Volume 8 Issue 2-3 Pages 70-73
    Published: June 30, 1962
    Released on J-STAGE: February 08, 2010
    JOURNAL FREE ACCESS
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  • MASAHISA SHINGU, SHIGERU YAMAMOTO, YOH NAKAGAWA
    1961 Volume 8 Issue 2-3 Pages 74-84
    Published: June 30, 1962
    Released on J-STAGE: February 08, 2010
    JOURNAL FREE ACCESS
    Vaccination with monovalent or trivalent Sabin's oral poliovirus vaccine has been progressing in Fukuoka Prefecture, Kyushu, Japan, since July 1961. By October 1961, approximately 762, 422 children representing 43.3% of the population under the age of ten years had been vaccinated.In relation to the prevention of poliomyelitis it is important to find out whatrange and degree the antibody formation would be stimulated by oral vaccination not only in general but especially in view of the interference of live vaccine to the other enteric viruses which are considered to be highly incident in Japan.The present studies were performed by the use of the serological method in order to clarify the antibody response of the vaccinated and unvaccinated children to the live poliovirus vaccine and, in addition, to infer the nature of the infection by the other enteric viruses, ECHO and Coxsackie virus strains.
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  • 1. INHIBITOR IN NORMAL MOUSE BRAIN FOR MOUSE ENCEPAHLOMYELITIS VIRUS GDVII STRAIN
    SAIZO YOSHIDA, MORITATSU MATSUMOTO, YOH NAKAGAWA
    1961 Volume 8 Issue 2-3 Pages 85-91
    Published: June 30, 1962
    Released on J-STAGE: February 08, 2010
    JOURNAL FREE ACCESS
    Following Francis' observation (1) of an inhibitor in normal serum for influenza virus hemagglutination, similar components inhibiting against a number of viruses were found to be wide-spread in tissue fluids and extracts.In 1951, Fastier (2) reported that the saline extract off normal mouse brain was capable of inhibiting hemagglutination by the GDVII strain of mouse encephalomyelitis virus. However, little is known about the nature of the inhibitor present in a normal mouse brain. This paper presents some characteristics of a hemagglutination inhibitor in a normal mouse brain for the virus.
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  • II. MECHANISM OF GDVII VIRUS HEMAGGLUTINATION INHIBITOR IN NORMAL MOUSE BRAIN
    YOH NAKAGAWA, SAIZO YOSHIDA
    1961 Volume 8 Issue 2-3 Pages 92-94
    Published: June 30, 1962
    Released on J-STAGE: February 08, 2010
    JOURNAL FREE ACCESS
    In the previous paper (1), we reported on the presence of a substance capable of inhibiting the GDVII strain of mouse encephalomyelitis virus in a normal mouse brain and en the nature of this inhibitor as mucoprotein. In the present paper an analysis of the mechanism of action of the inhibitor has been made and the results obtained will be reported.
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  • KOYO OKABE, NORIO ONO
    1961 Volume 8 Issue 2-3 Pages 95-99
    Published: June 30, 1962
    Released on J-STAGE: February 08, 2010
    JOURNAL FREE ACCESS
    Okabe and Tanaka (1958) reported the urine precipitin reaction for schistosomiasis japonica in 1958. In the field studies the authors sometimes met negative reaction among school children. A teacher asked children to bring the first morning urine for test. When children forgot the first urine, they might have brought the second or third urine specimen to our experiment. Experiments were conducted to examine the entire day's urine of schistosomiasis patients. At first sodium azide was used for the preservation of urine. This chemical is recently difficult to get, so merthiolate (Japanese name, Merzonin) was employed. Immunization of rabbits with the schistosomiasis patient's urine was tried in order to prove the presence of the antigen in the urine and to obtain antiserum for Schistosoma japonicum antigen.
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  • HIROSHI KAWAHARA
    1961 Volume 8 Issue 2-3 Pages 100-107
    Published: June 30, 1962
    Released on J-STAGE: February 08, 2010
    JOURNAL FREE ACCESS
    Gardner and Weiser (1947), Hauduroy et al. (1948), Penso et al. (1949) and Whittaker (1950) reported concerning mycobacteriophages. Their host mycobacteria were all saprophytic. Froman et al. (1953, 1954, 1959) isolated bacteriophages active against virulent Mycobacterium tuberculosis. But, these were reports about phage isolation and electronmicroscopic morphology. Recently in Japan, Takeya et al. (1957, 1958, 1959) discovered a method to isolate high titre phages. So, systematic studies of mycobacteriophages have been reported by many investigators. Sellers and Runnals (1961) reported on the physical and chemical characteristics and serological relationships of mycobacteriophages D28, D29 and D32. The present paper deals with the biological characterization of mycobacteriophages A6, B1 and C3, which have different host range specificity, and which were isolated in Japan by Takeya et al. The author wishes to make use of these characteristics in classification and genetics of mycobacteriophages.
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