抄録
In patients with acute myocardial infarction, reocclusion after achievement of coronary reperfusion by thrombolytic therapy using urokinase (UK) or tissue plasminogen activator (tPA) has become a problem. The causes of reocclusion may include rethrombosis as well as activation of platelets and coagulation factors by thrombolytic agents. To elucidate the mechanism of reocclusion involved, thrombin generation was measured. Coagulation of platelet-rich plasma was induced by CaCl_2. Each sample was reacted with S-2238 to determine the thrombin generation. UK or tPA was added to this system and the thrombin generation was assessed. The clotting time was shortened by UK and tPA when compared with control. Thrombin generation was increased by UK and tPA. Stimulation of thrombin generation by thrombolytic agents may contribute to reocclusion.
