抄録
Trichomycin exerted a considerable inhibitory effect upon the deamino-oxidation of such L-amino acids as L-alanine, L-proline, L-arginine, L-glutamic and L-aspartic acid by C. albicans in the concentrations below the minimal effective amount necessary in fungistasis. Furthermore, the oxidation of D-alanine and D-serine was completely or nearly completely inhibited by the addition of minute amounts of the drug. Also, the inhibiting action of the drug upon the metabolism of those L-and D-amino acids increased more and more with the lapse of time, and the inhibition rate of the drug constantly showed a high level rate.
Those respirometric data strongly suggest that trichomycin irreversibly inhibits, as an enzyme inhibitor, the deaminooxidation of amino acids by C. albicans, and the respiration inhibiting action of the drug is both more evident and more specific on the amino acid metabolism than that on the aerobic carbohydrate dissimilation. In regards to the mechanism by which the respiratory metabolism in the living cells of this organism is prevented by the addition of minute amounts of trichomycin, it is supposed that the drug may act on the flavin enzyme system which is directly connected with oxygen.
