Online ISSN : 1884-6440
Print ISSN : 0385-1036
ISSN-L : 0385-1036
製品 & 技術
徐放性微粒子を含有する徐放性口腔内崩壊錠・ハルナールD錠の開発
水本 隆雄
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ジャーナル オープンアクセス

2008 年 33 巻 2 号 p. 82-84

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Harnal D is a fast-disintegrating tablet containing fine, modified-release (MR) particles. The dissolution-controlled film on the MR particles consisted of a mixture of water-soluble and -insoluble polymers, with a very smooth particle surface (as determined by SEM observation). During dissolution testing, very fine pores on the surface of the MR particles were formed, and the drug release rate was controlled through these pores. The dissolution-controlled film was usually damaged during the compression process, and thus the dissolution rate increased. However WOWTAB technology, which was applied to Harnal D, can be manufactured at a low compression pressure, thereby avoiding damage to the dissolution-controlled film. In fact, there was no difference in the dissolution rate between the MR particles and tablet.

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© 2008 日本膜学会
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