抄録
A solid–in–oil (S/O)solution containing L–ascorbic acid phosphate magnesium salt (VC)was prepared to investi-gate the permeation behavior of VC into epidermis and dermis. The VC was coated with hydrophobic surfactant mol-ecules. Therefore, the coated–VC was well dispersed in an oil phase. Using a Yucatan micropig skin as a model skin,we validated if the S/O technique is applicable to carry a hydrophilic biomolecules into the cutaneous tissue. Theobservation of the cross-sectional skin by a fluorescent microscope confirmed that VC is present inside the skin tis-sue. The results indicated that the S/O solution can deliver VC into the skin. Since VC works as an inhibitor againstmelanin formation at epidermis and dermis, it is suggested that the VC–S/O solution can be applied to a whiteningagent and a cosmetic ingredient.
