抄録
Periodontitis is a chronic inflammatory disorder that causes deterioration of the periodontal tissues that support teeth. Several biomaterials, such as bone graft materials, barrier membranes and protein products, have been developed and used clinically to repair periodontal tissue defects clinically. However, it is difficult to regenerate the complete periodontal tissue structure. Recently, regenerative therapies using multipotent mesenchymal stromal cells (MSC) have been introduced to overcome the limitation of conventional procedures. These cytotherapies have been shown to be safe and effective for the treatment of periodontal tissue defects. In order to achieve more effective treatment, our strategy has been to integrate this stem cell biology and cell sheet engineering. This cell sheet technology has already been employed in clinical trials (one of these has already approved), confirming the safety and efficacy of the treatment method. In this review, we introduce recent progress in the engineering of cell sheets and review the potential of cell sheet technology for periodontal regenerative medicine.
