抄録
Drug delivery with nano–sized liposomes has been demonstrated to be useful for the treatment of cerebral ischemia/reperfusion (I/R) injury by passing through the disintegrated blood–brain barrier (BBB), whereas liposomal entry was limited at early phase after I/R. Since leukocytes can pass through the BBB by their membrane protein functions under cerebral I/R conditions, imparting leukocyte–mimicking properties to liposomes may allow the liposomes to overcome the BBB in the I/R region. In this review, we will introduce our recent findings about development of leukocyte–mimetic nanoparticles to overcome endothelial barriers, including the BBB.
