抄録
Extracellular vesicles (EVs) are nano–sized particles enclosed in lipid membranes that are released from cells. EVs play a crucial role in intercellular communication by transporting a wide range of molecules including nucleic acids, lipids, and proteins between cells. Moreover, due to their size of approximately 100 nm and low immunogenicity when derived from biological sources, EVs have garnered attention as promising carriers for drug delivery of small molecules, proteins, nucleic acids, and more. In the development of EVs as drug delivery carriers, three key points are crucial: efficient encapsulation of drug cargoes, effective cellular uptake, and targeted delivery to specific cells. Efforts to address these points often involve genetic engineering of the abundant proteins present in EVs. This review introduces the engineering of EVs for drug delivery carriers and discusses future prospects.
