抄録
18F–L–FBPA PET is expected to provide information on the biodistribution of L–BPA in vivo and on the tumor–to– normal tissue uptake ratio (T/N ratio), which can be used to estimate the therapeutic efficacy of boron neutron capture therapy (BNCT) and to support treatment planning. While the significance of PET imaging in BNCT has been increasingly recognized, fundamental studies on PET molecular probes, including synthetic methodologies, remain limited. Existing synthetic approaches for 18F–L–FBPA provide product yields sufficient for only one or two patients per synthesis, indicating a clear limitation from a radiochemical and production standpoint. To address this issue, a substantial improvement in the synthetic strategy is required to enable the preparation of larger quantities of the final radiopharmaceutical in a single production run. In this paper, we report the development of a new synthetic method for 18F–L–FBPA, aimed at improving production efficiency and supporting further basic and translational research in BNCT–related PET imaging.
