Sterilizing effectiveness of gamma radiation with Co^<60> or chemosterilants on the engorged female cattle tick, Boophilus microplus, was determined. Doses of 10 to 100 kr were inhibitory to oviposition. A 50% hatchability was shown by eggs deposited by females irradiated at a dose of about 0.5kr. Thiotepa was the most potent sterilant of the chemicals tested, and followed by apholate and metepa in this regard. Hempa was lower in the degree of effectiveness than any other chemicals tested. In these chemosterilants, a 50% sterilizing dose were in a range from 1.5 to 2500γ per gram of body weight by topical application. These results were similar to those obtained from many other insecti- and acaricides having an oviposition-inhibiting action upon the tick.