2018 Volume 61 Pages 77-83
Various fine particles have been actively researched for Drug Delivery System (DDS) in the recent drug development. We have been developing poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with bioactive substances for pharmaceutical preparations, medical devices, functional cosmetics and so on. Regarding the practical application, the PLGA nanoparticle’s weak points such as vigorous cohesiveness and low handling property have been dramatically improved by utilizing our powder processing technologies for designing composite particles. A lot of usefulness of our developed PLGA nanoparticles has been demonstrated in various administration routes. Clinical trials of preparations and devices using our PLGA nanoparticles have already been launched in Japan. Also we have found out the enhancement of drug’s skin permeability by PLGA nanoparticles. Base on the evidences, we have already succeeded in commercialization of functional PLGA nanoparticles for skincare cosmetics and hair growth tonic.
