Verification of Anti-wrinkle Effect by PLGA Nanoparticles

Abstract

Skincare has attracted public attention increasingly because of the increase in time spent at home due to refraining from going out and skin irritation caused by wearing masks for long periods. Attention is being paid to the next generation of skincare derived from regenerative medicine technologies to provide “curative therapy” for long-standing skin conditions such as wrinkles and blemishes. The raw materials for such cosmetics include eggshell membranes and human stem cell conditioned media. Because of the complexity of their constituents and their large molecular size, the problem with transdermal drugs is that they can’t penetrate sufficiently through the stratum corneum barrier, the first barrier to skin penetration, to the target site.

We have shown that poly-lactide-co-glycolide acid nanoparticles (PLGA NP) have skin permeability, the prolonged action of nanoparticle-encapsulated contents by sustained release effect of PLGA base, and cellular uptake ability of encapsulated contents. It indicates that PLGA NP can optimize the efficacy of the encapsulated contents in various cases.

In this paper, we report on the effectiveness of PLGA NP in improving dermal wrinkles of hydrolyzed eggshell membranes consisting of polymers.

Graphical Abstract