Development of Functional Cosmetic Materials Based on PLGA Nanoparticle Technology

Abstract

Background and Aims: In contemporary society, skincare and haircare have gained more attention, accelerated by the widespread adoption of online interactions and social media. Meanwhile, concerns such as skin dryness, wrinkle formation, and hair loss remain common issues, so more effective solutions are needed. We developed functional materials based on our proprietary poly (lactic acid-co-glycolic acid) nanoparticles (PLGA NP) technology to address these issues.

Methods and Results: Functional ingredients for improving skin barrier function, reducing wrinkles, and promoting hair growth were respectively encapsulated within PLGA NP. In vitro assays and monitor trials were conducted to verify their efficacy.

a) To enhance skin hydration, it is essential to improve the skin barrier function, which protects against external stimuli and retains moisture. We evaluated PLGA capsulex^® BasicCare, which encapsulates ingredients that support this function. Cellular assays demonstrated that BasicCare enhanced keratinocyte activation by 1.3-fold and upregulated the expression of genes associated with skin barrier function by 2.8-fold compared to the untreated group. Furthermore, skin hydration increased 2.7-fold, as confirmed by a monitor test.

b) For wrinkle reduction, stimulating the production of collagen and elastin—key proteins responsible for skin elasticity—is crucial, as fibroblasts play a role in their synthesis. We examined PLGA capsulex^® AgingCare, which encapsulates ingredients with wrinkle-improving effects. Cellular assays showed that fibroblast proliferation increased 1.4-fold in the AgingCare-treated group, leading to an at least 1.2-fold increase in collagen and elastin production. In addition, a five-week monitor trial demonstrated that the number of wrinkles decreased following continuous use of AgingCare.

c) Hair dermal papilla cells regulate hair follicle regeneration and the normal hair cycle transition, making their activation crucial for hair growth. We evaluated PLGA capsulex^® HairCare, which contains an ingredient with papilla cell-activating effects. Results showed a 1.4-fold increase in papilla cell proliferation in the HairCare-treated group. Gene expression levels involved in promoting hair growth were 2.8-fold higher than those in the untreated group.

Conclusions: The functional materials demonstrated significant effects in addressing specific skin and hair-related concerns. PLGA NP-treated groups exhibited significantly higher gene and protein expression levels compared to the untreated group and the functional component alone. These findings suggest that PLGA NP technology enhances cosmetic efficacy through its superior permeability and sustained release properties. Future challenges include more detailed efficacy verification and expanding applications to address additional beauty concerns. Overall, this research highlights the potential of nanotechnology in cosmetic science.