The effect of Bacillosporin A, from Taralomyces bacillosporus, on oxidative phosphorylation in mitochondria was examined. Bacillosporin A was found to uncouple the oxidative phosphorylation, causing 50% uncoupling at 5-7 μM, and to depress the state 3 respiration, causing 50% inhibition at 20 μM. Bacillosporin A inhibited the oxygen uptake of electron transport particles (ETP) oxidizing succinate, causing 50% inhibition at about 70 μM. But none of succinic dehydrogenase, succinic-cytochrome c reductase, and cytochrome c oxidase were speciffcally and strongly inhibited by this compound.References
