抄録
We studied that the effect of relatively low doses of five trichothecens (deoxynivalenol (DON), diacetoxyscirpenol (DAS), T-2 toxin (T-2), fusarenon-X (FX) and nivalenol (NlV)) on the host resistance against Salmonella infection using mice. Mice given daily each trichothecene in drinking water were infected orally with Salmonella enteritidis 14 days after the commencement of exposure to trichothecens. It was found that DON was most effective among five trichothecene derivatives in decreasing the resistance against Salmonella infection. This effect of DON was associated with the reduction of serum anti-Salmonella 1 gM titer and delated type hypersensitivety reaction, both of which are regarded as defense mechanisms against Salmonella infection. These results suggest that dietary exposure to low doses of DON enhances the susceptibity to oral infection to Salmonella through toxic effects on cellular and humoral immunity.
