アルミナ担持塩化銅(II)によるフェノール類の位置選択的塩素化
1987 年 1987 巻 9 号 p. 1753-1755
詳細
1987 年 1987 巻 9 号 p. 1753-1755
Alumina-supported copper (II) chloride was found to be very effective for the regioselective chlorination of phenol and alkylphenols. The chlorination of phenol with CuCl2/Al2O3 at 50°C for 1 h in acetonitrile gave a 75% yield of a mixture of p- and o-chlorophenol with parafortho ratio of 22. Alkylphenols were also selectively chlorinated under similar co nditions to give the corresponding chloroalkylphenols in high yield. As the size of alkyl group becomes larger, the rate and the selectivity decrease.
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