パン酵母による環状β-ケトエステルのジアステレオならびにエナンチオ選択的還元に及ぼす酵母の固定化およびアルコール添加物の効果
1994 年 1994 巻 1 号 p. 86-88
詳細
1994 年 1994 巻 1 号 p. 86-88
The reduction of racemic ethyl 2-oxocyclohexanecarboxylate (1) by the use of normal dry bakers'yeast (Free BY) or calcium alginate-immobilized bakers' yeast (IM-Alg) gave ( + )-1R, 2S-2-hydroxy ester (2) exclusively, while considerable amount of the corresponding ( + )-1S, 2S-2- hydroxy ester (2)was obtained together with ( + )-1R, 2S-2-hydroxy ester (2) in the presence of allyl alcohol. The ratio of the cis isomer (1R, 2S) to the trans isomer (1S, 2S) was about 7:3∼6:4 and the enantiomeric purity of each isomer was very high. In contrast, the reduction of 1 by the use of polyurethane-immobilized bakers' yeast (IM-PU) gave a mixture of ( + )-1R, 2S- and ( + )-15, 2S-2-hydroxy esters (7: 3) in the absence of allyl alcohol.
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