N-アセチルフルフリルアミンを原料とする5-アミノレブリンの実用的合成

抄録

5-Aminolevulinic Acid (ALA) is known as a selective herbicide and one of the agricultural chemicals which promote the growth of plants. The authors studied on the practical synthesis of ALA from Nacetylfurfurylamine (AcFA). AcFA was converted to 2-acetamidomethy1-2, 5-dimethoxy-2, 5-dihydrofuran by electrolytic or bromine-methanol oxidation. It was changed to the tetrahydro compound by catalytic reduction with Raney Ni under ordinary temperature and pressure. The tetrahydro compound was oxidized to N-acetyl-ALA with potassium permanganate in a diluted sulfuric acid solution. N-Acetyl-ALA gave ALA hydrochloride by the hydrolysis with diluted hydrochloric acid. Overall yield of ALA hydrochroride was about 42%.