抄録
Background Since hyperuricemia has been linked with an increased risk of atherosclerotic cardiovascular disease, we examined the effects of aging and BW changes on serum uric acid (UA) concentrations.
Methods The subjects were 5309 men (51.8±8.5 years old) and 3080 women (51.0±8.4 years old) who visited our hospital for a health check-up. Serum UA was compared according to age in men and women, and before and after menopause in women. Serum UA and the frequency of hyperuricemia were compared between groups with and without metabolic syndrome. Annual changes in serum UA were examined and correlated with changes in BMI.
Results Serum UA was higher in women aged over 50 years old. In a group of women in whom serum UA was measured before and after menopause, the level was higher after menopause (4.6±1.0 vs.4.3±0.9mg/dl, p<0.001). Serum UA and the frequency of hyperuricemia were higher in men and women with obesity, hypertriglyceridemia or hypertension. Serum UA decreased (6.0±1. I to 5.7±1.1 mg/dl, p<0.001)with a decrease in BMI, and increased (6.2±1.2 to 6.4±1.3 mg/dl, p<0.05) with an increase in BMI in men.
Conclusion Serum UA increases after menopause in women and is related to obesity and other parameters associated with metabolic syndrome in men and women. Management of BW of subjects with hyperuricemia may be important to prevent onset of atherosclerotic disease.
