2016 年 3 巻 1 号 p. 7-12
Objective: Several studies have indicated that there is a link between atherosclerosis and bone metabolism. We investigated a cross-sectional relationship between bone mineral density (BMD) and metabolic biomarkers among postmenopausal women who underwent a comprehensive health check-up.
Methods: Three hundred and eighty-six postmenopausal women, mean age 63.3 ± 8.3 years, were enrolled in this study. BMD at the lumbar spine and unilateral proximal total hip was measured by dual-energy X-ray absorptiometry, and the percentage of young adult mean (%YAM) was calculated. The lower %YAM of the two sites was used for analysis. We performed logistic regression analyses to evaluate factors related to the risk of low BMD, defined as %YAM < 80. Plausible variables, i.e. age, body mass index (BMI), blood pressure, fasting plasma glucose, triglycerides (TG), low-density lipoprotein cholesterol, alkaline phosphatase, C-reactive protein, smoking habit, drinking habit, and exercise habit were included in the model.
Results: One hundred and twenty-six participants were considered to have low BMD. Univariate logistic analyses adjusted for age and BMI revealed that TG was related to the risk of low BMD (odds ratio and 95% confidence interval; log TG by 1SD increase: 1.335 (1.038–1.707), p< 0.05). In the multivariate models adjusted for all other confounders, this significant relationship remained (odds ratio and 95% confidence interval; log TG by 1SD increase: 1.385 (1.056–1.818), p< 0.05).
Conclusions: These results suggest that, in addition to age and BMI, TG is a risk factor contributing to low BMD.
