2021 年 8 巻 1 号 p. 9-16
Objective: We aimed to elucidate the relationships among hyperuricemia, nonalcoholic fatty liver disease (NAFLD), and other lifestyle-related diseases.
Methods: We enrolled 420 subjects who had a complete medical check-up at Tokyo Women’s Medical University between June 2016 and December 2017. Risk factors related to NAFLD or hyperuricemia were analyzed by contingency tables using multivariate logistic regression. Statistical significance was set at p<0.05.
Results: NAFLD was significantly related to homeostasis model assessment-insulin resistance (≥2.5) and hyperuricemia (>7 mg/dL). Central obesity and impaired fasting glucose, which are components of metabolic syndrome (MetS), were significantly associated with NAFLD. MetS was also significantly associated with NAFLD. The following were identified as risk factors for hyperuricemia: sex (male), dyslipidemia (increased low-density lipoprotein cholesterol), hyperinsulinemia, NAFLD, eGFR (<60 mL/min/1.73 m2), and alcohol overuse. Furthermore, central obesity and dyslipidemia (decreased high-density lipoprotein cholesterol and/or high triglycerides) were significantly associated with hyperuricemia.
Conclusions: Hyperuricemia and NAFLD are related to one another, to MetS, and to other lifestyle-related diseases. Thus, effective treatment of NAFLD and hyperuricemia is vital, which requires both medication and lifestyle modification approaches.
