抄録
In order to investigate a genetic aspect of congenital functional and/or biochemical anomalies of the skin, chromosome analysis of cells cultured from the leucocyte component of the blood obtained from six cases of keratosis palmaris et plantaris hereditarium, nine of ichthyosis vulgaris, two of keratosis follicularis, two of Darier’s disease, one of dyschromatosis symmetrica hereditaria, two of xeroderma pigmentosum and six of atopic dermatitis were performed, revealing following results.
1) Long Y chromosome was found in one case of ichthyosis vulgaris.
2) One case of keratosis palmaris et plantaris hereditarium showed low modal cell percentage, compared with control, which was statistically significant (p>0.05).
3) In one case of keratosis palmaris hereditarium and one of xeroderma pigmentosum, the rates of appearance of hyperdiploid cells were significantly higher than in control (p<0.05).
4) In one case of xeroderma pigmentosum and two of atopic dermatitis, the occurence of breaks was more frequent than in control, which was statistically significant (p<0.05).
5) Aneuploid cells and structual abnormalities of chromosomes showed a tendancy to appere more frequently in the group of functional and/or biochemical anomalies, such as keratosis follicularis, Darier’s disease, dyschromatosis symmetrica hereditaria, xeroderma pigmentosum and atopic dermatitis than in the group of organic anomalies such as phacomatosis and nevus described in the 1st report.
