Electronmicroscopic and Immunohistochemical Studies in Pustulosis Palmaris et Plantaris

Abstract

Thirty biopsies were taken from eighteen patients in pustulosis palmaris et plantaris. The specimens were examined electronmicroscopic and immtmohistochemically. The pustule wall consisted of epithelial cells, which contained various stages of keratinization. Desmosomes of pustule wall epithelial cells were partially disappeared, spongiosis and acantholysis were recongnized. In the altered epithelial cells intracellular organelles were also degenerated. In the nucleus of the epithelial cells inclusions bodies were existed, but the nature of their bodies was unknown. Within pustules, polymorphous leukocytes degenerated and showed abnormal appearance. The polymorphous leukocytes incorporated I¹³¹ γ-globulins and contained γ-globulin diffusely in the cytoplasm.