Intraosseous lipoma is a benign bone tumor. We report a case of intraosseous lipoma of the proximal humerus. A 51-year-old man presented with a history of gradually increasing right shoulder pain on motion. Plain radiographs revealed a 2 × 3 cm osteolytic lesion in the right proximal humerus. CT showed a low-density area in the bone, identical to the findings in the normal adipose tissues. On MRI, the lesion had high signal intensities on both T1-weighted and T2-weighted images. On MRI with fat suppression, the lesion was suppressed. Curettage of the lesion and artificial bone grafting were performed. Histological examination revealed mature fat cells, and intraosseous lipoma was diagnosed. Since then, the patient had been free from symptoms, and there was no recurrence identified on plain radiographs six months following the surgery.
