14 cases of osteosarcoma of the lower limb have been treated in our clinic since 1955. There are ten males and four females, ranging of age in 3 years old to 44 years old (average 18.8 years old). The lesion is at the femur in 8 cases and at the tibia in 6 cases. Our regime of treatment can be divided into three category, that is, radical operation following chemotherapy in 3 cases from 1955 to 1958, arterial perfusion following radical operation with radiation therapy in 4 cases from 1959 to 1968 and arterial perfusion followng raidical operation with chemotherapy in 7 cases from 1969 to 1979. Only 3 cases survived over 5 years. Relation between regime of treatment and the results was studied in this paper. Best results were obtained in the last group.
