血清トランスアミナのゼとその肝障害における意義

抄録

SGO-T and SGP-T activity were measured spectrophotometrically.
The average value of SGO-T for normal young adults was 13.9±3.8, ranging from 6 to 23 units, and that of SGP-T was 5.6±1.8, ranging from 3 to 9 units.
The activity of enzymes was found to be remarkably increased in hepatitis, especially in its earlier stage.
In acute hepatitis, the average value of SGO-T was 771 units and that of SGP-T was 717 units, gradually decreasing to normal range within about 1 month, though BSP test, serum bilirubin and serum iron still remained abnormal.
The average value of SGO-T was 59.1 units in patients with liver cirrhosis, and 84.8 units in obstructive jaundice, and 84.8 units in hepatic carcinoma.
On the other hand, that of SGP-T was 56.1 units in liver cirrhosis, and 71.9 units in obstructive jaundice, and 44.4 units in hepatic carcinoma.
The activity of enzyme was compared with the results of usual liver function tests, especially BSP test, serum bilirubin and serum iron etc., but the correlation between them was not significant.
The measurement of transaminase alteration was found to be a useful tool in the diagnosis and study of acute liver disease and was considered to be a reliable indicater reflecting acute hepatocellular damage.
The value of SGP-T activity was higher than that of SGO-T in experimentally produced toxic hepatitis and obstructive jaundice, however, such a definite finding was not observed in clinical cases with these conditions.
In order to clarify the mechanism of the elevation of enzyme activity in peripheral blood, a series of experimentations was attempted.
In experimental CCl₄ toxic hepatits, the height and duration of increased enzyme activity was found be proportional to the extent of hepatocellular damage, and the release of GO-T from damaged liver was proved in hepatic venous blood using hepatic vein catheterisation.
And in experimental ligation of biliary tract the stagnation of bile was seemed to attribute to the elevation of enzyme activity.
As to the SGP-T elevation, the same mechanism was suggested, but in this case, the stagnation of bile seemed to play more important role than in elevation of SGO-T.