腹膜吸収能亢進因子に関する実験的研究

抄録

We have never seen any practical method to examine the peritoneal function.
But the new method using phenolsulfonphthalein (i. e. Matsunaga-Matsuda's method) made it (peritoneal function) possible clinically by measuring absorption capacity of peritoneum.
The author researched for the promoting factors upon the absorption capacity using rabbit, judging from the experimental data by means of Matsunaga-Matsuda's method.
(1) When “Strong Neo-Minophagen C” was injected to the experimental animals either intravenously or intramuscularly, the absorption capacity was remarkably increased and by repeating same injections this capacity was more increased and the effect of its accumulation was manifest.
In order to research the true nature being contained in this drug, he examined each element which composes “Strong Neo-Minophagen C”, i. e. glycyrrhizin, glycine and cysteine. From these experiments he resolved that glycyrrhizin showed no effect but glycine and cysteine, especially the latter showed the remarkable absorptional capacity.
(2) In the experiment using “polytamin”, a combined amino acid drug, it provedthe same increased function as glycine indicated. He thought this increased function using these drugs was chiefly based upon the hypermetabolism caused by the specific dynamic action of amino acid. For this reason, cysteine had activating factor for proteolytic enzyme and had a anticoagulating activity and had a activating factor for pro teolytic enzyme and had a anticoagulating activity, thus resulting the increase of peritoneal function and circulating blood volume in the peritoneum, therefore cysteine showed, the author concluded, especially high activating factor for the peritoneal function.
(3) In the experiment on patient using the blocking agent for autonomous nerve, the author observed in case of T. E. A. B., slightly increased function, but almost uneffected in case of hexamethonium bromide. And in case of chlorpromazin, decreased function. Concerning the result of T. E. A. B., the author thought this increased function might be due to the dilatation of arteriole caused by the blocking of sympathic nerve. And in order to certify this slightly increasing function, he resected the splanchnic nerve per peritoneally in animal and he was able to explain hat the decreased function in case of using chlorplomazine was due to the inhibitance of intestinal peristalsis and paretic function of colonic cell.
(4) Purine derivate had more effective to increase the peritoneal function than saline and mercurial diuretics did.
(5) Cortison had remarkably decreased this function and DOCA slightly. These two experimental facts were thought to be resulted from the inhibiting function from the saline metabolism and from the diffusion by these steroid hormones.
(6) Expecting to increase the absorbed function, by spreading factor, “Hyaluronidase” injected into the peritoneal cavity, the author observed slightly decreased value against his anticipation.