脂肪肝•脂肪性肝硬変における肝内血管の変化に関する実験的研究

II 前硬変•早期肝硬変期の変化

抄録

An attempt was made to investigate the correlation between intra-hepatic vascular changes and histogenesis of fatty cirrhosis in the rats fed with a choline-deficient diet prescribed by Hartroft for 1 to 6 months. Intra-hepatic vascular changes were observed by a mean of a prepara tion of the liver infused with colored plastik or gelatin solutions. Progression of fatty liver and cirrhosis was evaluated histologically by the criteria of Hoffbauer et al. Portal pressure was appraised from intra-splenic pressure.
Liver cirrhosis was found in over 90% of rats fed with a choline-deficient diet for 6 months. Portal pressure showed a tendency to increase with histological progression of the liver. Distortion of the hepatic and portal veins and anastomoses between each of the terminal branches of the hepatic vein were observed in the liver having slight to moderate fibrosis (stage 3A). In the reconstructed liver by fibrous band without regeneration nodules (stage 3B), features of compression in the small hepatic and portal veins, anastomoses between the hepatic and portal veins or each of the portal veins, and disorganization of the vessels in the area surrounded by fibrous band were observed. When regenerating nodules developed in the scattered area of the liver (stage 4A), the intra-nodular vessels were compressed toward outside of the nodules, showing basket-like appearance, and this feature was prominent near by the terminal hepatic veins. When development of regeneration nodules became marked (stage 4B), conspicuous compression of relatively large vessels in the both veins, especially in the hepatic vein, was observed. Blood supply through the portal vein was preserved in each nodule. And some nodules were supplied portal blood through one terminal branch and the others were done through 2 or more branches.
These results would indicate that hepatic fibrosis was preceeded by the changes in the hepatic veins, and intra-hepatic vascular changes became prominent with progress of liver cirrhosis. The differences of blood supply in each nodule may influence on futher progression of liver cirrhosis.