Astroprotein (GFAP) Levels in Cerebrospinal Fluid of Stroke Patients

Toru HAYAKAWA; Yukitaka USHIO; Yasutaka MAEDA; Norio ARITA; Toshiki YOSHIMINE; Mamoru TANEDA; Tadayoshi IRINO; Kazuyoshi MORIMOTO; Takesada MORI; Heitaro MOGAMI

doi:10.2176/nmc.24.13

Toru HAYAKAWA, Yukitaka USHIO, Yasutaka MAEDA, Norio ARITA, Toshiki YOSHIMINE, Mamoru TANEDA, Tadayoshi IRINO, Kazuyoshi MORIMOTO, Takesada MORI, Heitaro MOGAMI

著者情報

キーワード: astroprotein, GFAP, cerebroprotein, cerebrospinal fluid, stroke, cerebral hemorrhage

ジャーナルフリー

1984 年 24 巻 1 号 p. 13-18

DOI https://doi.org/10.2176/nmc.24.13

詳細

抄録

Radioimmunoassay was employed to study the astroprotein (Ap)—an astrocyte-specific cerebroprotein which is immunologically identical to glial fibrillary acidic protein (GFAP)—levels in the cerebrospinal fluid (CSF) of stroke patients in the acute or subacute stage. These levels tended to increase in the acute stage, especially in cases with intracerebral hemorrhage. The increases were related to the size of the lesion and the patients' general neurological state. The post-ictal increases were more rapid in cases with intracerebral hemorrhage than with cerebral infarction; both exhibited a correlation between the CSF-Ap levels in the acute stage and the prognosis.

責任著者(Corresponding author)

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