抄録
Systematic anterior pituitary function tests were performed in 12 patients with cerebral arteriovenous malformation and 7 patients with unruptured giant cerebral aneurysm, and the results were assessed for correlation with clinical factors. In the radio-immunoassay, growth hormone and cortisol were determined during the insulin tolerance test (regular insulin, 0.15-0.20 U/kg), luteinizing hormone and follicle stimulating hormone under luteinizing hormone-releasing hormone (100 μg), thyroid stimulating hormone and prolactin under thyrotropin-releasing hormone (500 μg). The results were as follows. 1) In the cerebral arteriovenous malformation group, growth hormone and cortisol secretions were impaired in 33% and 17% of the cases, respectively. The case incidence of impaired anterior pituitary hormonal secretion was 33%, and it was lower than in other groups. 2) In the unruptured giant cerebral aneurysm group, growth hormone, cortisol, follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, and prolactin secretions were impaired in 71%, 29%, 14%, 14%, 14%, and 14% of the cases, respectively. The case incidence of impaired anterior pituitary hormonal secretion was 86%, but the intensity was mild in most patients. Hypothalamic panhypopituitarism was noted in one patient with a giant aneurysm at the right internal carotid-ophthalmic artery junction. 3) The effects of stress, age, drugs, and hormonal diseases must be considered in an exact evaluation of the anterior pituitary function in patients with cerebrovascular disease.
