Abstract
Intracranial aneurysms found in three out of eight siblings in one family are presented, with a review of ninety-six sibling cases in the literature.
The eight siblings comprised four brothers and four sisters. Patients suffering from subarachnoid hemorrhage were the third sister, aged 57 years, and the eldest brother, aged 65 years. They were successfully treated by clipping of the ruptured aneurysms. The eldest sister, aged 72 years, was shown to have an unruptured aneurysm by angiography.
Ninety-nine reported cases of sibling aneurysms including the present three cases were analyzed from the view points of familial relationship, age at onset, sex incidence, and location of aneurysm. Compared with intracranial aneurysms in the general population, aneurysms in sibling cases had a lower incidence of anterior cerebral or anterior communicating artery aneurysms, and a higher incidence of middle cerebral artery aneurysms. In cases where more than two siblings suffered from subarachnoid hemorrhage, other members were reported to have an increased risk of intracranial aneurysm. An angiographical investigation should be considered in such cases.
