抄録
Combination therapy with human fibroblast interferon (Hu IFN-β) and 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) was administered against a cell line of human malignant glioma transplanted into nude mice, and the histological changes were examined. The mice were divided into four groups (control, Hu IFN-β ACNU, and combination therapy). The drugs were administered intraperitoneally.
As in an earlier in vitro study, 22) the anti-proliferative effect in the combination therapy group was significantly greater than that in the other groups. In the combination therapy group the histological findings also revealed more degenerative changes, such as a tendency for tumor cells to separate from each other, an increase in multinucleate giant cells, and extensive necrosis.
As an adjunct to surgery, combination therapy with Hu IFN-β and ACNU may be a significantly effective treatment for malignant gliomas.
