Cell Kinetics of Intracerebrally Implanted RG-C6 Tumors in Rats —Effects of Intracarotid Hyperosmolar Mannitol measured by <SUP>3</SUP>H-thymidine Autoradiography and Bromodeoxyuridine Uptake—

Tooru INOUE; Toru IWAKI; Masashi FUKUI; Iwao TAKESHITA

doi:10.2176/nmc.28.533

Cell Kinetics of Intracerebrally Implanted RG-C6 Tumors in Rats

—Effects of Intracarotid Hyperosmolar Mannitol measured by ³H-thymidine Autoradiography and Bromodeoxyuridine Uptake—

Tooru INOUE, Toru IWAKI, Masashi FUKUI, Iwao TAKESHITA

著者情報

キーワード: RG-C6 tumor, cell kinetics, bromodeoxyuridine, ³H-thymidine, blood-brain barrier

ジャーナルフリー

1988 年 28 巻 6 号 p. 533-537

DOI https://doi.org/10.2176/nmc.28.533

詳細

抄録

The proliferative activity of intracerebrally implanted rat glioma C6 (RG-C6) tumors in rats was examined by means of ³H-thymidine autoradiography and measurement of bromodeoxyuridine (BrdU) uptake. The effect of intracarotid hyperosmolar mannitol on the cell kinetics of the RG-C6 tumors was studied by the latter method. The labeling index (LI) and distribution of ³H-thymidine-labeled cells were identical to those of the BrdU-labeled cells. The LIs of BrdU-labeled cells were not altered by intracarotid mannitol injection. The influence of intracarotid hyperosmolar mannitol infusion not only on brain tumors but also on normal brain tissue is discussed.

責任著者(Corresponding author)

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