Effect of Long-term Treatment with Somatostatin Analogue (SMS 201-995) on Pituitary Tumor Shrinkage in Acromegaly —Report of Two Cases—

Kazutoshi MUKADA; Tohru UOZUMI; Akihiko TAKECHI; Kazunori ARITA; Takashi YANO; Taizo HIROHATA; Jun ONDA; Masahiro OHTA

doi:10.2176/nmc.32.215

Kazutoshi MUKADA, Tohru UOZUMI, Akihiko TAKECHI, Kazunori ARITA, Takashi YANO, Taizo HIROHATA, Jun ONDA, Masahiro OHTA

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Keywords: acromegaly, somatostatin analogue, tumor shrinkage, pituitary adenoma

JOURNAL FREE ACCESS

1992 Volume 32 Issue 4 Pages 215-219

DOI https://doi.org/10.2176/nmc.32.215

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Abstract

The effect of long-term somatostatin analogue (SMS 201-995) treatment in two acromegalic patients is reported. Continuous tumor shrinkage was observed even after 129 and 139 weeks of treatment with 600μg of SMS 201-995 daily. A huge and firm adenoma underwent shrinkage during treatment with SMS 201-995. No serious side effect appeared during 160 weeks of treatment. SMS 201-995 has a longterm tumor shrinkage effect and improves endocrinopathies.

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