1949 Volume 23 Issue 1 Pages 22-26
To elucidate the relationship between the position of double bonds in hydronaphthalene and its physiological activity I intended to study hydronaphthaleneacetate. First, 1, 2, 3, 4-tetrahyd-ronauhthalene (1) acetate and 1, 2, 3, 4-tetrahydronaphthalene (2) acetate were synthesized from 1, 2, 3, 4-tetrahydronaphthalene by the condensation-method of hydrochloric acid and formalin according to the next formula;
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The position of acetic-radical in these substances was decided by esterification and oxydation of them. According to Raphanus-test, the physiological activity of 1, 2, 3, 4-tetrahydro (1) naphthaleneacetate was generally equal to that of α-naphthaleneacetate.