Aspergillus versicolorの代謝生産物に関する研究

(第4報) Versicolorin及び種種のHydroxyxanthoneの抗菌性

抄録

It was observed that versicolorin and norsteriigmatocystion had strong antibiotic properties against Mycobacterium phlei, Mycobacterium avium and Mycobacterium tuberculosis var. homnis H. 37. Rv.
The experimental results by dilution method showed that versicolorin and norsterigmatocystin of 100, 000 dilutions had antibiotic activity against M. phlei and M. avium, and versicolorin of 50, 000 dilutions and norsterigmatocystin of 80, 000 dilutions had antibiotic activity against M. tuberculosis var. homnis H. 37. Rv.
The results of experiments on mice showed that toxicity of these substances had L. D₅₀_??_20mg.
Besides, the following nine xanthones which had similar structure to that of norsterigmatocystin were synthesized:
1-hydroxyxanthone, 1, 3, 6-trihydroxyxanthone,
1, 3, 7-trihydroxyxanthone, 1, 3, 8-trihydroxyxanthone,
1, 3, 5, 6-tetrahydroxyxanthone, 1, 3, 5, 7-tetrahydroxyxanthone,
1, 3, 5, 8-tetrahydroxyxanthone, 1, a, 6, 7-tetrahydroxyxanthone,
1, 3, 6, 8-tetrahydroxyxanthone.
Of the above-mentioned, 1, 3, 6-trihydroxyxanthone and 1, 3, 8-trihydroxyxanthone were synthesized for the first time by the authors. These substances of 40, 000_??_80, 000 dilutions had antibiotic activity against M. tuberculosis var. homnis H. 37. Rv.