2022 年 2 巻 1 号 p. 9-15
Purpose: Sodium copper chlorophyllin (SCCP) is known to have various effects such as antiallergic and tissue-activating effects, and in recent years is expected to be effectively used in the medical field. Moreover, in the field of dentistry, it is used for treating periodontal disease and trauma. Although there are many reports on the effects of SCCP, few reports have examined how it works. In this study, to elucidate the effects of SCCP on periodontal tissue, we studied physiological changes in vitro in human gingival fibroblasts (HGF) exposed to SCCP.
Methods: Human gingival fibroblasts were cultured in 15% FBS-containing DMEM. The cells were exposed to SCCP (5 nM, 10 nM, 100 nM, 1 μM, 10 μM), and cell proliferation and mitogens were examined.
Results: Cell proliferation increased significantly with 100 nM SCCP, and an increase in mitotic factors that promoted cell proliferation was observed.
Conclusion: The results suggested that 100 nM SCCP stimulates cell division factors of human gingival fibroblasts and promotes cell proliferation, thereby promoting wound healing.
