Abstract
After the removal of chief lymphoid organs such as the mesenterial mass of nodes, vermiform appendix and spleen as well as other several small lymph nodes in adult rabbits, there appeared a new formation of lymphocyte aggregations in the periportal spaces of the liver to a large extent and, though to a lesser extent, also in the femoral bone marrow. This phenomenon is considered to be compensatory to the reduction in the mass of lymphoid tissue.
In contrast with th i s, compensatory hyperplasia on the part of the remaining lymph nodes and lymphoid tissues took place only to a small extent. There was no local regeneration of lymph nodes when they had been completely removed.
The fact tha t a compensatory reaction in response to a marked reduction in the mass of lymphoid tissue takes place to the greatest extent in the liver was stressed.
The author wishes to thank P rofessor B. Osogoe, at whose suggestion this work was undertaken, for his kind interest during the course of the work and in the preparation of the manuscript.
