Abstract
A cytological study was made of the anterior hypophysis of mice placed in a hot box at temperatures of 34° to 38°C for a period of 1 to 65 days.
1. Mark e d cytological changes in acidophils were not found throughout the whole period of this work.
2. Two types of basophils showed apparently significant cytological changes. The number of beta-cells showed a normal value on the 1st to 4th days of this work, a moderate decrease on the 5th to 16th days and increase on the 20th to 60th days. At the end of this work, the beta-cells appeared to approach the normal level. Degranulation and vacuolization of the cytoplasm occurred throughout the whole period, especially on the 7th to 9th days, whereas regranulation of beta-cells was observed in the latter half of this work.
The delta-cells increased in number on the 1st to 35th days. After about the 40th day, the number of delta-cells seemd to remain at the normal level. Degranulation and vacuolization of the cytoplasm were obsevered during the first half of this work.
3. Chromophobes showed no change in number and cytological detail throughout the whole period of this work.
