Abstract
Chromosomes of 8 normal chorionic villi,15 hydatidiform moles,6 destructive moles and 4 chorioepitheliomas were studied. Normal chorionic villi were characterized by either normal male or female diploid cells with a sharp mode. Two hydatidiform moles were provided with triploid cells. The remaining 13 hydatidiform moles showed a modal number of 46 with frequent occurrence of tetraploid and aneuploid cells. Destructive moles showed a decrease of orthoploid cells with a marked occurrence of aneuploid cells. In chorioepitheliomas, aneuploid cells were consistently predominant in cell population. Possible inference was induced that aneuploidization of chromosomes seems to play a significant role in the malignant transformation of cell population.
Acknowledgement: The authors are very grateful to Dr. Motomichi Sasaki for his friendly assistance in preparing this manuscript with expert advice.
