Organ Biology
Online ISSN : 2188-0204
Print ISSN : 1340-5152
ISSN-L : 1340-5152
大腸癌肝転移形成早期において, Kupffer 細胞は転移抑制的に機能する.
松村 英樹近藤 匡小川 光一田村 孝史福永 潔大河内 信弘
ジャーナル フリー

2015 年 22 巻 2 号 p. 184-192


In this study, to clarify the role of Kupff er cells (KCs) in the liver metastasis, we eliminated KCs at diff erent time points before or after injection of tumor cells (TCs). Our results suggested that the role of KCs was suppressive especially in the early stage of liver metastasis. In addition, we used intravital microscopy (IVM) to analyze the sinusoidal dynamics of both KCs and TCs in colon cancer metastasis to the liver. IVM showed that TCs adhered to KCs from the early time after TC injection. The KCs phagocytosed the TCs, which adhered with the KCs. It is suggested that KC phagocytosis of TCs in the early stage of liver metastasis strongly suppressed the formation of the liver metastatic nodules thereafter.

© 2015 日本臓器保存生物医学会
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