めまい症に対するイソプロテレノール徐放剤 (KIP) の二重盲検法による使用経験

抄録

Isoproterenol has a potent dilating effect on the peripheral blood vessels.
A total of 45 patient with vertigo were treated by three different methods with isoproterenol; in the first group by a combination of isoproterenol hydrochloride (10mg) and pronase 3.75mg (KIP-01); in the second group, isoproterenol hydrochloride only (10mg) (KIP-02) and in the third group by pronase (3.75 mg) (KIP-03).
Improvement of subjective symptoms was seen in 86.7% in the first group, 66.7% in the second group and 53.3% in the third group.
Objective improvement of the findings was seen in 73.3% in the first group, 66.7% in the second group and 20.0% in the third group.
The results were tested statistically by x² test, which showed no significant difference in alleviation of subjective symptoms but significant difference was demonstrated between the first group and the third group (1%), between the second group and the third group (5%) while no significant difference was seen between the first group and the second group.
The results indicate that isoproterenol has beneficial effect on the control of vertigo.