抄録
The clinical course, histological findings, treatments, and other characteristics in 4 cases of his own and 429 others reported in the literature are reviewed.
The authors summarized the characteristics of this disease as follows.
1. This is a chronic and benign disease found chiefly in young males.
2. The main signs are development of masses in the subcutaneous soft tissue suchas parotid, submandibular, or buccal region, and generalized enlargement of superficial lymph nodes independently or in combination. Furthermore, in some cases, there are complaints of pruitus and pigmentation at the site of swelling.
3. Histological picture of such masses or lymph nodes shows neoplastic or hyperplastic lymph follicular structure accompanied by large, well defined germinal centers, and at the same time marked infiltration of eosinophils can be seen in the interfollicular tissue.
4. Leukocytosis, eosinophilia, and an increase of serum IgE are found in the majority of the cases.
5. There are many reports which consider the disease an atopic allergy or a Type I allergic reaction whose allergen is Candida albicans.
6. The authors observed that the frequency of recurrence in the cases treated by surgery alone or by corticosteroids alone was high, and the response to Oxyphenbutazon and irradiation was good. It is concluded that this disease should be treated in combination with surgery, chemotherapy and irradiation rather than by a single modality of treatment alone.
