抄録
Operative findings in recurrent cholesteatomas that followed intact canal wall tympanoplasty are often suggestive of invagination of the canal skin into the non-ventilated cavity.
Animal experiments using rabbits to produce a similar condition revealed active proliferation of the epithelial cells of the canal wall.
The obstruction of the tympanie isthmus in a chronically inflamed ear appeared to play an important role in the early stage of the development of cholesteatoma.
Radiological findings that inflammation of the mastoid cavity brings about depression of normal pneumatization have been seen both in pigs and children.
All of the above finidngs in both clincal and experimental studies were suggestive of the fact that many cholesteatomas in man are due to invagination of the epithelial layer into the non-ventilated middle ear or associated clefts.
