抄録
As an approach to immunological onset mechanism of otitis media with effusion (OME), the authors measured concentrations of immunosuppressive acidic protein (IAP) and immunosuppressive substance (IS) in the middle ear effusion by the single radial immunodiffusion method.
In 34 ears of 34 patients, a mean IAP concentration in serous middle ear effusion (MEE) was 789.4±325.3 μg/ml and a mean IS concentration in MEE was 1082.8±327.9 μg/ml. In the patients, a mean serum IS level was 391.8±169.0μg/ml and a mean serum IS level was 694.7±224.1μg/ml. In 24 healthy people, a mean serum IAP level was 381.3±104.5μg/ml and a mean serum IS level was 509.7±104.4μg/ml. Thus, the mean IAP and IS concentrations in MEE were significantly higher (p<0.01). IAP and IS, immunosuppressive substances, seem to be involved in pathogenesis of serous OME.
