抄録
In order to investigate OME from the systemic perspective, we have studied histological reactions of the mucous membrane in the bilateral middle ears in the sensitized animals. Histological changes of the middle ear mucosa in the sensitized ear were characterized by hypertrophy of mucosa with fibrosis. Numerous mononuclear cells also existed. In non-sensitized ear (opposite side), the changes were edema of the mucosa showing mild proliferation of fibroblast and vasodilation. Mainly mononuclear cells were scattered.
For the purpose of researching the mechanism of the histologic change of the opposite ear (non-sensitized ear), the immunohistologic examination and the measure of the circulating immune complex were performed. As a result, the mucosal response was based on the immune complex.
