抄録
Using an antigen-induced otitis media (OM) model in chinchillas sensitized with human serum albumin (HSA), we studied the antiinflammatory effect of a corticosteroid and kallikrein inhibitor (aprotinin) by both biochemical and cytological analyses of middle ear fluid (MEF). The levels of HSA, α1-antitrypsin and total protein concentration were measured in the MEF to evaluate the degree of OM. Both vascular leakage and leukocyte infiltration were significantly reduced by corticosteroid and inhibitor treatments. In conclusion, the kallikrein-kinin system is related to the early stage of antigen-induced OM.
